Journal: bioRxiv
Article Title: Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies
doi: 10.1101/2024.05.07.592955
Figure Lengend Snippet: (A) Aldosterone precursors: mice bearing 5 mm HAC15 tumors were given angiotensin II (5μg/g) and then euthanized 30, 60, 90, 120, or 240 minutes afterward to determine at what time point peak precursor concentrations were reached; (B) Aldosterone: mice bearing 5 mm HAC15 tumors were given angiotensin II (5μg/g) and then euthanized 30, 60, 90, 120, or 240 minutes afterward to determine at what time point peak aldosterone concentration was reached; (C-E) Mice bearing 5 mm HAC15 tumors compared to non-tumor bearing mice; (C) progesterone concentrations ; (D) deoxycorticosterone concentrations ; (E) aldosterone concentrations. * = significant difference (p<0.05).
Article Snippet: The HAC15 human adrenocortical carcinoma cell line was purchased from ATCC (Manassas, VA).
Techniques: Concentration Assay